Liodis et al., 2007) and SOX6 (Azim et al., 2009 Batista-Brito et al., 2009). The largest fraction (about 60–70%) of cortical INs is generatedįrom NKX2.1-expressing progenitors located in the medial ganglionic eminence (MGE) (Butt et al.,Ģ008 Xu et al., 2008) and their specification is under the control of the TFs LHX6 (Du et al., 2008 Their fate specification (Kessaris et al., 2014 Anastasiades and Butt, 2011 Flames et al., 2007 Cortical INs are generated in a variety of subpallial regions and the combinatorial expression of transcription factors (TFs) in these domains is believed to play a critical role in Different subtypes of cortical interneurons (INs) emerge during development and their specification arises through the complex interaction of cell-intrinsic mechanisms and cell-extrinsic cues (Bartolini et al., 2013 Fishell and Rudy, 2011 Huang, 2014 Synchronizing network rhythms and regulating behavioral states (Cardin et al., 2009 Fu et al.,Ģ014 Kepecs and Fishell, 2014 Pfeffer et al., 2013 Pi et al., 2013 Pinto and Dan, 2015 Subtypes, which play critical roles in controlling the firing rate of glutamatergic pyramidal neurons,
Of INs with a unique developmental trajectory and open the possibility to study their specificįunctional contribution to cortical inhibitory microcircuit motifs.Ĭortical microcircuit function relies on the coordinated activity of a variety of GABAergic interneuron Overall, these results indicate that NGCs are a distinct class PROX1, NR2F2, the marker reelin but not VIP and exhibited the molecular, morphological andĮlectrophysiological profile of NGCs. Hmx3-derived 5-HT3AR+ cortical interneurons (INs) expressed the transcription factors Originate from a specific pool of 5-HT3AR-expressing Hmx3+ cells located in the preoptic area Using in vivo genetic lineage-tracing in mice, we report that NGCs Trajectory of neurogliaform cells (NGCs), the main effectors of a powerful inhibitory motif recruitedīy long-range connections. Processes such as their developmental specification. Still unclear how current classifications of cortical interneuron subtypes relate to biological
Of Basic Neuroscience, University of Geneva, Geneva, SwitzerlandĪbstract Delineating the basic cellular components of cortical inhibitory circuits remains aįundamental issue in order to understand their specific contributions to microcircuit function. Mathieu Niquille1,2†, Greta Limoni1,2†, Foivos Markopoulos2†,Ĭhristelle Cadilhac1,2, Julien Prados1,2, Anthony Holtmaat2, Alexandre Dayer1,2*ĭepartment of Psychiatry, University of Geneva, Geneva, Switzerland 2Department
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